Study Of Biogenically Fabricated Transition Metal Oxides Nanoparticles On Oral Cavity Infectious Microbial Strains

The selected six specific bacterial and fungal strains, which caused oral teeth decay were analyzed by antimicrobial iron oxide (Fe2O3), copper oxide (Cu4O3), and zinc oxide (ZnO) nanoparticles synthesized byaloe barbadensisleaves extract, using agar well diffusion method with 0.9% saline solution. TMOs comparatively had not been focused on oral cavity infectious pathogens to analyze antimicrobial activity. In the present study, TMOs were characterized by UV, SEM, FTIR, and XRD. Oral infectious strains (Escherichia coli, Bacillus subtilis, Bacillus licheniformis, Klebsiella pneumonia)and fungal strains (Aspergillus niger,Candida albicans) were used as test microorganisms. The effect of different concentrations of TMO-NPs (2.5 mu g/mL, 5 mu g/mL, 10 mu g/mL) was studied by zone of inhibition (ZOI), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The zinc oxide nanoparticle with least particle-sized (37.8 nm) exhibited highest antimicrobial activity. In future, these zinc-oxide nanoparticles may be used in medicine for oral infectious diseases treatment.