Design, stereoselective synthesis, computational studies and cholinesterase inhibitory activity of novel spiropyrrolidinoquinoxaline tethered indole hybrid heterocycle

Natarajan Arumugam,Abdulrahman I. Almansour,Raju Suresh Kumar,Santhakumar Yeswanthkumar,Ramanathan Padmanaban,Yuvaraj Arun,Sevgi Kansız,Necmi Dege,Thota Sai Manohar,S. Venketesh

Journal of Molecular Structure（2021）

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摘要

•A novel spiropyrrolidine heterocyclic hybrid was achieved in good yield.•Structural aspects were done using spectroscopic and X-ray diffraction analysis.•Regioselectivity and possible transition states were investigated by DFT studies.•AChE and BChE inhibitory activity observed.

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关键词

Spiropyrrolidines,Quioxalinone,1,3-dipolar cycloaddition, dft-calculation,X-ray diffraction analysis,Molecular docking simulation

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