Basal Notch1 And Notch4 Activation As Potential Markers Of Aggressiveness And Sensitivity To Notch Inhibition In Human Cancer Cell Lines

Background. Notch pathway is involved in tumor biology including cell proliferation, migration, drug resistance, and epithelial-to-mesenchymal transition (EMT). Notch activation leads to a proteolytic cleavage, followed by the release of the Notch intracellular domain (NICD), which translocates into the nucleus and activates target genes. Notch1 and Notch4 expressions were described as mutually exclusive in some tumors, with an increased aggressiveness linked to low Notch1/high Notch4 expression phenotype. What about the role of their basal activation in cancers? The aim of this work is to characterize the role of basal Notch1 and Notch4 pathway on cell proliferation, motility and sensitivity to Notch inhibition in human pancreatic (PDAC), headn 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3684.