Synthesis And Ultrasound Mediated Antibacterial Activity Of Ferrocene-Triazole-Porphyrin Derivative

The [3 + 2]-cycloaddition reaction of various azides with ferrocenylmethylpropargyl ester in the presence of copper (I) salt lead to the formation of ferrocenyl-containing derivatives, including porphyrin, which exhibit pronounced cytotoxicity against Escherichia coli under ultrasound irradiation.The [3 + 2]-cycloaddition reaction of azides with ferrocenylmethylpropargyl ester in the presence of copper(I) salt leads to derivatized ferrocenes with linked porphyrins. These ferrocene-modified porphyrins exhibited pronounced cytotoxicity against Escherichia coli under ultrasound irradiation.