Formulation of water-insoluble antineoplastic agents as nanosuspensions using NANOEDGE formulation technology

632 Water-insoluble antineoplastic agents pose a formulation problem inasmuch as sufficient plasma levels of drug are required to achieve adequate efficacy and toxicity levels in suitable animal models and humans. For this purpose, a nanosuspension formulation platform (NANOEDGE) has been developed which potentially permits high drug loading, eliminates undesirable solvents, and allows administration of the same formulation through various routes, e.g., oral and injectable including I.V. The steps involved in formulating 3 different antineoplastic compounds, using this technology, to attain stable nanosupensions with mean particle size