Methotrexate-induced cutaneous ulceration and necrosis in chronic atopic dermatitis

Malika A. Ladha,Bryn Edgerton,Jonathan Levy,Muhammad N. Mahmood,Alim R. Devani,Parbeer S. Grewal,Vimal H. Prajapati

JAAD Case Reports（2020）

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摘要

Methotrexate is a folic acid antagonist used to treat malignant and inflammatory diseases.1 Cutaneous ulceration and necrosis is a rare adverse event. Within dermatology, this phenomenon has occurred almost exclusively in psoriasis.2 We present a case of methotrexate-induced cutaneous ulceration and necrosis in chronic atopic dermatitis.

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