A framework for grouping and read-across of nanomaterials- supporting innovation and risk assessment

•The GRACIOUS Framework supports industrial and regulatory users to streamline innovation and risk assessment of nanomaterials.•The GRACIOUS Framework guides users to identify the most appropriate hypothesis that defines how specific nanoforms can be grouped.•Tailored Integrated Approaches to Testing and Assessment allow the user to gather evidence to test their grouping hypothesis.•The GRACIOUS Framework combines outputs of the IATA into a data matrix to support risk decision making or risk assessment.