Design, synthesis, biological assessment and molecular docking studies of some new 2-Thioxo-2,3-dihydropyrimidin-4(1H)-ones as potential anticancer and antibacterial agents

•Thiouracil derivatives are precursor for anticancer activity.•Pseudomonas aeruginosa is an important cause of persistent infections due to its acquired multidrug resistance, its virulence factors and its biofilms form.•Thiouracil derivatives are recently used as antibiofilm and antivirulence activities.