Childhood Survivors Of High-Risk Neuroblastoma Show Signs Of Immune Recovery And Not Immunosenescence

Petra Lázničková,Tomáš Kepák,Marcela Hortová – Kohoutková,Luděk Horváth,Kateřina Sheardová,Rafal Marciniak,Carmine Vacca,Michaela Šiklová,Teresa Zelante,Lenka Rossmeislová,Zdenka Křenová,Jaroslav Štěrba,Kamila Bendíčková,Jan Frič

EUROPEAN JOURNAL OF IMMUNOLOGY（2020）

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摘要

Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8(+)T cell compartment and elevated plasma TNF-alpha but in later follow-up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors.

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adverse late effects, childhood, immune recovery, immunosenescence, neuroblastoma

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