Proof of ChIP selectivity in myometrial tissues.

Applied anti-H3K27ac ChIP in murine myometrial tissue (target, pink) and murine embryonic stem cells (cell control, blue) revealed enrichment or lack of enrichment at select gene targets, as expected. Cell-specific enrichment of this histone mark observed at gene promoters expected to be active predominantly in myometrium rather than embryonic stem cells (left), in both cell types (center), and in neither cell type (right). Data associated with this figure can be found in S4 Data. ChIP, chromatin immunoprecipitation; H3K27ac, H3 acetylation on lysine residue 27. (PDF)