Monitoring Skin Metastases During Immuno- And Targeted Therapy Using Total-Body 3d Photography

Eruptive skin metastases in melanoma are an uncommon manifestation of rapidly progressive, systemic disease1 . Type and kinetics of these lesions have not been analyzed before, because of the rarity of the event and technical restrictions of total-body photography. We present the first sequential total-body 3D photography-based analysis by a VECTRA 360WB imaging system of a melanoma patient suffering from disseminated, spreading skin metastases under treatment with immune checkpoint antibodies and subsequent BRAF/MEK inhibition.In April 2019 a 54-year-old male patient with BRAF V600E-mutated conjunctival melanoma developed pigmented skin (Fig. 1a), brain, pulmonary, and hepatic metastases. In addition to a cerebral stereotactic radiotherapy the patient received four cycles of a combined immunotherapy with ipilimumab (1mg/kg) and pembrolizumab (2mg/kg).