Biochemical Timekeeping Via Reentrant Phase Transitions

Journal of Molecular Biology（2021）

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摘要

•Reentrant phase transitions involve a round trip between two material states.•Reentrant liquid–liquid phase separation (LLPS) of proteins can be tuned by RNA.•Reentrant LLPS can manifest as condensates with layered functional topologies.•Reentrant LLPS may enable timekeeping via self-limiting reactions.

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关键词

phase separation,reentrant phase transitions,disordered proteins,transcription,RNA,condensates

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