Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort

Sonia L Robinson,Xuehuo Zeng,Weihua Guan,Rajeshwari Sundaram,Pauline Mendola,Diane L Putnick,Robert A Waterland,Chathura J Gunasekara,Kurunthachalam Kannan,Chongjing Gao,Erin M Bell,Edwina H Yeung

Environmental Research（2021）

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摘要

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent organic pollutants which may alter prenatal development, potentially through epigenetic modifications. Prior studies examining PFOS/PFOA and DNA methylation have relatively few subjects (n < 200) and inconsistent results.

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关键词

Persistent organic pollutants,Newborn dried blood spots,Mother-child dyads,Developmental origins of health and disease (DoHaD)

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