ANALYSIS OF MICROCIRCULATORY DISORDERS IN PATIENTS WITH LICHEN RUBER PLANUS OF ORAL MUCOSA

At the dental appointment, there is an increasing frequency of lichen planus in the oral cavity. In this case, erosive-ulcerous form of lichen planus is one of the most common and difficult to treat. At present, issues of aetiopathogenesis of lichen ruber planus in geriatric dentistry are not yet clear. In this work, development of inflammatory-destructive diseases is dealt with from the standpoint of microcirculatory disorders in patients' oral cavity. To study microcirculatory changes in patients with erosive ulcerous form of lichen ruber planus, a comparative analysis of microcirculatory component and amplitude-frequency spectrum was carried out in patients with this pathology with respect to a group of healthy people aged 45-59. Material and methods. Microcirculation was studied with Doppler laser flowmetry in 60 patients in comparison with healthy people (30 people). Results. Hemocirculatory disorders were revealed in patients both on the side of pathology and in the symmetric area, which indicates systemic microcirculatory changes in the oral cavity. Discussion. The data obtained suggest that it is advisable to perform laser Doppler flowmetry prior to and against the background of pharmacotherapy. Conclusion. In inflammatory-destructive lesions of the oral mucosa, increased microcirculation parameters against the background of decreased average perfusion fluctuation and vasomotor activity of the vessels is observed. The amplitude-frequency spectrum, carried out by wavelet transform, showed a decrease in the amplitude of low-frequency flaws and an increase in the amplitude of pulse and respiratory waves. Endothelial oscillations decay probably occurs against the background of decreased synthesis of nitric oxide; as the frequency range of secretory activity of the endothelium and synthesis of nitric oxide coincide in the microcirculatory bed, functional relationship between these parameters can be traced. Vasomotor rhythm decline, vasoconstriction of the vessels, decrease in endothelial oscillations amplitude indicate endothelial dysfunction. Having high sensitivity to changes in the microhemodynamic situation in the vascular bed, the use of LDF makes it possible to evaluate the state of functioning of control mechanisms and is a valid method of application in gerontostomatological practice.