In Vitro Activity of Synthesized Pyran Derivatives-Inhibitor Against Prostate Cancer

In this study, four novel pyran derivatives (1-4) were synthesized and their structures were clarified by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. Their in vitro proliferation inhibitory activities against four human prostate cancer cell lines (LNCap, PC3, DU145 and PC-3M-2B4) were then evaluated. The experimental results showed that compared with compounds 1 and 2, compounds 3 and 4 with two strong electron- withdrawing groups in the phenyl ring exhibited better anti-cancer activity.