Two Novel Mg (II) and Ho (III) Complexes Based on the Same Ligand Inhibit Growth of Human Lung Cancer Cells

Two new three-dimensional (3D) metal-organic frameworks, namely {[Mg-3(DTDN)(3)(H2O)(6)] (DMF)(2)}(n) (1, H2DTDN = 6,6'-dithiodinicotinic acid) and {[Ho-2(DTDN)(3)(H2O)(5)]center dot 7H(2)O}(n) (2) have been successfully prepared under solvothermal or hydrothermal conditions. The analysis results show that complex 1 is a 2-fold interpenetrated framework structure with a hxg topological network and complex 2 features a 3-D network with an uncommon twofold interpenetrating four-connected CdSO4 structure. In addition, in vitro anticancer activities of compounds 1 and 2 on four human lung cancer cell lines (H1299, MSTO-211H, PC9 and A549) was further determined.