Synthesis and Antimicrobial Testing of some Quinazolinone Compounds

Since tens of years, the design and discovery of new antimicrobial drugs to overcome the present microbial resistance to different drugs is a medical and pharmaceutical priority. In this research, we designed and synthesized new 4(3H) quinazolinone compounds and tested them against different microorganisms. Two microbiological testing methods were used for exact results. The in vitro antimicrobial estimations of the synthesized compounds were tested against three strains; the different types of pathogenic microorganisms were Gram-positive and Gram-negative bacteria. Some of these candidates, i.e. 19, 20, 21, 29, 30, 31 and 35 showed inhibition zone with Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The MIC values of the extreme active compounds versus the test organisms S. aureus as Gram-positive as well as E. coli, and P. aeruginosa as Gram-negative was evaluated. It could be concluded that the proposed molecular structural countenances for these compounds appeared considerable for prospectively investigable new antimicrobial agents.