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Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes

Jennifer Wessel,Timothy D Majarian,Heather M Highland,Sridharan Raghavan,Mindy D Szeto,Natalie R Hasbani,Paul S de Vries,Jennifer A Brody,Chloé Sarnowski,Daniel DiCorpo,Xianyong Yin,Bertha Hidalgo,Xiuqing Guo,James Perry,Jeffrey R O’Connell,Samantha Lent,May E Montasser,Brian E Cade,Deepti Jain,Heming Wang,Peitao Wu,Silvia Bonàs-Guarch,Ricardo D’Oliveira Albanus,Aaron Leong,Irene Miguel-Escalada,Arushi Varshney,Gregory L Kinney,Lisa R Yanek,Leslie Lange,Marcio Almeida,Juan M Peralta,Stella Aslibekyan,Abigail S Baldridge,Alain G Bertoni,Lawrence F Bielak,Donald W Bowden,Chung-Shiuan Chen,Yii-Der Ida Chen,Seung Hoan Choi,Won Jung Choi,Dawood Darbar, James S Floyd,Barry I Freedman,Mark O Goodarzi,Ryan Irvin,Rita R Kalyani,Tanika Kelly,Seonwook Lee,Ching-Ti Liu,Douglas Loesch,JoAnn E Manson,Rami Nassir,Nicholette D Palmer,James S Pankow,Laura J Rasmussen-Torvik,Alexander P Reiner,Elizabeth Selvin,Aladdin H Shadyab,Jennifer A Smith,Daniel E Weeks,Lu-Chen Weng,Huichun Xu,Jie Yao,Zachary Yoneda,Wei Zhao,Jorge Ferrer,Anubha Mahajan,Mark I McCarthy,Stephen Parker,Alvaro Alonso,Donna K Arnett,John Blangero,Eric Boerwinkle,Michael H Cho,Adolfo Correa,L. Adrienne Cupples,Joanne E Curran,Ravindranath Duggirala,Patrick T Ellinor,Jiang He,Susan R Heckbert,Sharon Lr Kardia,Ryan W Kim,Charles Kooperberg,Simin Liu,Steven A Lubitz,Rasika A Mathias,Stephen McGarvey, Braxton D Mitchell,Alanna C Morrison,Patricia A Peyser, Bruce M Psaty,Susan Redline,Dan Roden,M. Benjamin Shoemaker,Nicholas L Smith,Kent D Taylor,Ramachandran S Vasan,Karine A Viaud-Martinez,Jose C Florez, James G Wilson,Robert Sladek,Josée Dupuis,Stephen S Rich,Jerome I Rotter,James B Meigs,Alisa K Manning

user-5da93e5d530c70bec9508e2b（2020）

引用 6|浏览90

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摘要

Type 2 diabetes is increasing in all ancestry groups. Part of its genetic basis may reside among the rare (minor allele frequency

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关键词

Minor allele frequency,Whole genome sequencing,Heritability,Type 2 diabetes,Genetics,Biology

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