PTH1-34 inhibited TNF-α expression and antagonized TNF-α-induced MMP13 expression in MIO mice

•PTH1-34 has an obvious analgesic and anti-inflammatory effect in MIO mice.•PTH1-34 antagonized TNF-α-induced MMP13 expression via the NF-κB signaling pathways in chondrocytes.•PTH1-34 inhibited TNF-α expression via the PKA pathway in synovial cells.