Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review

Frontiers in Neuroendocrinology(2021)

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摘要
•This review catalogues the effects of physical and/or psychosocial stress in rodents.•Different types of stress induce subtly different behavioural and biological phenotypes.•The combined effect of multiple stressor types results in a more severe pathological state.•This review will help animal researchers more appropriately design their experiments.
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关键词
Depression,Anxiety,Chronic stress,Stressor type,Hypothalamic pituitary adrenal (HPA) axis activity,Inflammation,Neuroinflammation,Hippocampal neurogenesis,Neural plasticity
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