Antigen specificities and functional properties of MR1-restricted T cells

Gennaro De Libero,Andrew Chancellor,Lucia Mori

Molecular Immunology（2021）

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摘要

•MR1, a non-polymorphic ubiquitous antigen presenting molecule presents small metabolites to T cells.•MR1T cells recognize small drugs and microbial metabolites presented by MR1.•MR1T cells also recognize self-metabolites accumulating in tumor cells.•MR1T cells are multi-functional and express polyclonal TCR heterodimers.

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关键词

MR1,Self-antigen,Antigen presentation,MR1T cells

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