The Ups And Downs Of The Striatum: Dopamine Biases Upstate Balance Of Striosomes And Matrix

NEURON（2020）

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摘要

Prager et al. demonstrate an opposite regulation of activity in striosomes and matrix of the striatum. By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine release can extend upstates in matrix D1-expressing direct pathway projection neurons (dSPNs) but shorten them in striosomal dSPNs.

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