Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrast

•SynthSR turns clinical scans of different resolution and contrast into 1 mm MPRAGEs.•It relies on a CNN trained on fake images synthesized on the fly at every minibatch.•It can be retrained for any combination of resolutions / contrasts without new data.•It enables segmentation, registration, etc with existing software (e.g. FreeSurfer) Code is open source.