Manganese-enhanced MRI: Comparison of agents in the rat pancreas

Lucy E Kershaw,David ML Lilburn,Maurits A. Jansen,Andrew R Bond,Salamah M Alwahsh,Pilar Jimenez-Royo,Antonella Napolitano,Philip Murphy,Alexandra Roberts, Rob Janiczek,Shareen Forbes,Scott IK Semple

Journal of Magnetic Resonance Open（2019）

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摘要

•Three different Manganese-based contrast agents produced enhancement in the pancreas of normal rats.•Enhancement after glucose challenge was greater than enhancement after saline challenge.•Both Mangafodipir and Manganese gluconate show potential for clinical translation investigating beta cell imaging of the pancreas in diabetic patients.

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关键词

Manganese,Diabetes,Pancreas,β-cells,Pancreatic islets

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