Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates

Yuxing Xia,Zhijuan Chen,Guilian Xu,David R Borchelt,Jacob I Ayers,Benoit I Giasson

Neuroscience Letters（2021）

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摘要

•Series of novel monoclonal antibody target misfolded SOD1 that causes ALS.•Antibodies to exposed SOD1 electrostatic loop preferentially detect SOD1 aggregates.•Comparative detection of SOD-1 aggregates with Campbell-Switzer silver staining.

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关键词

Amyotrophic lateral sclerosis,Antibodies,Frontotemporal dementia,Pathology,Silver stain,Superoxide dismutase 1

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