The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats

•Suppression or genetic deletion of GPER could induce depressive or anxiety-like symptoms in female animals.•Intracerebroventricularly activation GPER by G-1 exhibited antidepressant and anxiolytic-like effects in OVX female rats.•G-1 alleviated hippocampal redox status in OVX female rats.•G-1 accelerated PKA activation and enhanced TSPO phosphorylation.•PKA antagonist PKI partially antagonized the anti-anxiety and anti-depression effects of G-1.