Microvascular Changes At Different Stages Of Chronic Kidney Disease

Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 +/- 8.9 and 48.8 +/- 7.9 ml/min/1.73 m(2) for stage 2 and 3 CKD, respectively. CRAE and CRVE in zones B and C were significantly lower in patients with stage 3 CKD compared to patients with stage 2 CKD (CRAE-B:141.1 +/- 21.4 vs. 130.5 +/- 18.9 mu m, p = .030; CRAE-C:137.4 +/- 19.4 vs 129.2 +/- 18.2 mu m, p = .049; CRVE-B:220.8 +/- 33.0 vs. 206.0 +/- 28.4 mu m, p = .004; and CRVE-C:215.9 +/- 33.0 vs. 201.2 +/- 25.1 mu m, p = .003). In patients with stage 2 CKD, CRAE-B was higher than CRAE-C (141.1 +/- 21.4 vs. 137.4 +/- 19.4 mu m, p < .001). In contrast, such a difference was not found in patients with stage 3 CKD. CRAE of both retinal zones correlated with eGFR for the entire cohort. In patients with stage 3 CKD, retinal narrowing is more pronounced compared to patients with stage 2 CKD. Whether the novel observation of difference in arteriolar caliber between zones B and C in stage 2 CKD could serve as an early marker of CKD progression warrants further investigation.