Shared DNA methylation signatures in childhood allergy: The MeDALL study Cheng-Jian Xu , Olena Gruzieva , Cancan Qi , Ana Esplugues , Ulrike Gehring , Anna Bergström , Dan Mason , Leda Chatzi , Daniela Porta , Karin C Lodrup Carlsen , Nour Baïz , Anne-Marie Madore , Harri Alenius , Bianca van Rijkom , Soesma A Jankipersadsing , Pieter van der Vlies , Inger Kull , Marianne van Hage , Mariona Bustamante , Aitana Lertxundi , Matias Torrent , Gillian Santorelli , Maria Pia Fantini , Vegard Hovland , Giancarlo Pesce , Nanna Fyhrquist , Tiina Laatikainen , Martijn C Nawijn , Yang Li , Cisca Wijmenga , Mihai G Netea , Jean Bousquet , Josep M Anto , Catherine Laprise , Tari Haahtela , Isabella Annesi-Maesano , Kai-Håkon Carlsen , Davide Gori , Manolis Kogevinas , John Wright , Cilla Söderhäll , Judith M Vonk , Jordi Sunyer , Erik Melén , Gerard H Koppelman Journal of Allergy and Clinical Immunology（2021）
摘要
Reduced whole blood DNA methylation at 21 CpGs was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis and eczema.
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关键词
Epigenetics, DNA methylation, allergy, IgE, children
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