Combined application of MRS and DWI can effectively predict cell proliferation and assess the grade of glioma: A prospective study

•MRS and DWI can effectively predict cell proliferation before operation.•DWI can make up for the shortcomings of MRS.•MRS combined with DWI can further improve sensitivity and specificity in predicting the grade of Glioma.•Fisher's linear discriminant functions is an ideal predictive LDA model for diagnosing and differentiating LGG from HGG.