LiBr-catalyzed one-pot three-component domino strategy toward the construction of beta-phosphonomalonates scaffolds in aqueous conditions

LiBr-mediated domino Knoevenagel-phospha-Michael strategy has been established for the synthesis of beta-phosphonomalonates under aqueous conditions. It is noteworthy that the developed protocol is effective with a wide range of aldehydes to deliver a diverse range of beta-phosphonomalonates in good to excellent yields. The mild reaction conditions, easier procedure, use of aqueous media, inexpensive and water tolerant property of LiBr are important advantages of this protocol.