Antipsychotics in routine treatment are minor contributors to QTc prolongation compared to genetics and age

L. Hommers,M. Scherf-Clavel,R. Strempel, J. Roth,M. Hohner, B. Pfuhlmann,M. Mattheisen,J. Deckert,M. Gawlik,S. Unterecker

PHARMACOPSYCHIATRY（2021）

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摘要

Individual genetic factors and age are main determinants of the QT interval. Antipsychotic drug serum concentrations within the therapeutic range contribute to QTc prolongation on an individual level.

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关键词

QT prolongation,antipsychotic medication,polygenic score,psychotic disorder

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