CILIARY DYSFUNCTION AND RESPIRATORY EPITHELIAL ULTRASTRUCTURAL ABNORMALITIES ARE FEATURES OF COPD IRRESPECTIVE OF EXACERBATOR PHENOTYPE

INCREASED UPREGULATION OF LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1 (LAMP-1) IN THE AIRWAY WALL OF COPD IS ASSOCIATED WITH DECREASED PHYSIOLOGICAL OUTCOMES AND POTENTIAL ROLE IN AUTOPHAGY MATHEW EAPEN, PHIL HANSBRO, ELIZABETH TAN, CHRIS WARD, HAYDN WALTERS, SUKHWINDER SINGH SOHAL NHMRC Centre for Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, Australia, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia, Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom, and School of Health Sciences, Faculty of Health, University of Tasmania, Launceston, Australia