Potency Of Titanium Dioxide Nanoparticles On Skin Wound Healing In Rats

Wound is as damage or disruption to the normal anatomical structure and function, it can range from a simple break in the epithelial integrity of the skin or it can be deeper, extending into subcutaneous tissue. Titanium dioxide nanorods (TiO2-NRs) were biosynthesized abundantly and confirmed its rod shape with the dimensions of 244-246 nm length and 532-649 nm diameter, respectiely. Chicken embryo chrioalantonic membrane (Cam) ascular assay was used in studying angiogenesis of prepared TiO2-NRs and proed that both 10 and mu g/0.2ml showed goog angiogenesis effect as ealuated by microscopical examination for collateral proliferation of blood essels and histological examination of the traeted fertile chicken's eggs CAM. Also, the dose 20 mu g/0.2ml TiO2-NRs showed actiity of angiogenesis better than 10 mu g/0.2ml TiO2-NRs. The effects of different concentration TiO2 nanoparticles on wound healing in Albino rats were used for ealuating the macroscopic and the microscopic effect of skin wound dressing on angiogenesis and wound healing. The animals of un-treated by phenytoin as standard healing promoting drug (control positue)drug, 10 mu g/200 mu l and 20 mu g/200 mu l groups showed thickening of epidermis at its cut edges. The dermis near the excision area was rich in polymorphonuclear cells which represent the inflammatory cells. The obtained results proved that dressing with TiO2-NRs showed promoting effect on wound healing. it is adisable to be used with other medication to cut short the time of wound healing and further inestigation has to be done to clarify the exact mechanism of TiO2-NRs promotes wound healing.