Sustainable chemo-enzymatic preparation of enantiopure (R)-beta-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous "click" cycloaddition reaction in deep eutectic solvents

Enantiomerically pure (R)-beta-hydroxy-1,2,3-triazole derivatives, which are important beta-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid bacterium (Weissella cibaria C43-11) and a "click" cycloaddition reaction carried out in deep eutectic solvents, under heterogeneous and aerobic conditions at room temperature.