Clinical Implications Of Minimal Residual Disease Detection In Infants With Kmt2a-Rearranged Acute Lymphoblastic Leukemia Treated On The Interfant-06 Protocol

This study provides support for the idea that induction therapy selects patients for subsequent therapy; infants with high EOI MRD may benefit from AML-like consolidation (DFS 45.9% 23.2%), whereas patients with low EOI MRD may benefit from ALL-like consolidation (DFS 78.2% 45.0%). Patients with positive EOC MRD had dismal outcomes. These findings will be used for treatment interventions in the next Interfant protocol.