Hydrogen sulfide: Recent progress and perspectives for the treatment of dermatological diseases

•Three hydrogen sulfide (H2S) production enzymes including CSE, CBS and 3-MST exist in the skin.•H2S regulates burn, diabetic skin wound, psoriasis, systemic sclerosis, melanoma, and pruritus.•H2S regulates oxidative stress, inflammation, angiogenesis and apoptosis in skin diseases.•Some ideal characteristics of H2S-based therapeutics for topical delivery are preferred.•Therapeutic potential of H2S for skin disorders will be further proposed in clinical trials.