Senescence in RASopathies, a possible novel contributor to a complex pathophenoype

Melanie Engler,Miray Fidan,Sayantan Nandi,Ion Cristian Cirstea

Mechanisms of Ageing and Development（2021）

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摘要

•Senescence is associated with ageing.•RAS-MAPK pathway has a major role in senescence.•Patients with RAS-MAPK developmental disorders (RASopathies) display features of premature ageing.•Senescence in RASopathy may be an underestimated contributor to RASopathy pathophenotype and a premature ageing.

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关键词

Senescence,Oncogene-induced senescence,Germline mutations,RAS-MAPK,RASopathy,Costello syndrome,Noonan syndrome,Cardio-facio-cutaneous syndrome,Premature ageing

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