p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling

Haiyang Yu,Yi Cheng,Guorui Zhang,Xueting Wang,Wen Gu,Xuejun Guo

Life Sciences（2021）

引用 9|浏览9

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摘要

•The expression of p62 is up-regulated in airway remodeling of chronic asthma.•p62 is involved in BSMCs proliferation and migration via controlling glycolysis.•p62 regulates glycolysis via the mTOR/c-Myc/HK2 pathway.

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关键词

p62,Autophagy,Aerobic glycolysis,hexokinase2,Airway remodeling

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