New Furo[3,2-H]Isochroman From The Mangrove Endophytic Fungus Aspergillus Sp. 085242

Four new compounds, asperisocoumarin G (1), asperisocoumarin H (2), (+/-)-asperisocoumarin I [(+/-)-3], along with the known pergillin (4) and penicisochroman L (5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I (1-3) were new isocoumarins belonging to the class of furo[3, 2-h]isocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for their alpha-glucosidase inhibitory effects, and compounds 1 and 4 showed moderate alpha-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of 3 showed antibacterial activity against Salmonella.