Process Development Overcomes a Challenging Pd-Catalyzed C–N Coupling for the Synthesis of RORc Inhibitor GDC-0022
Organic Process Research & Development（2020）
Key words
retinoic acid receptor-related orphan receptor gamma,RORc,sultam,Buchwald-Hartwig C-N coupling,reaction progress kinetic analysis,benzylation,heterogeneous reactions
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