Sirtuin1 contributes to the overexpression of Giα proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats.

Yuan Li,Ekhtear Hossain,Nahida Arifen,Ashok K Srivastava, Madhu B Anand-Srivastava

FASEB JOURNAL（2022）

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摘要

In summary, our results demonstrate that Sirt1 is overexpressed in VSMC from SHR which through augmenting oxidative stress contributes to the enhanced expression of Giα proteins, cell cycle proteins and resultant hyperproliferation of VSMC.

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关键词

cyclinD1/Cdk4, Gi alpha proteins, oxidative stress, proliferation, spontaneously hypertensive rats, sirtuin1, vascular smooth muscle cells

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