Evaluation of the bioactive properties of Alternanthera sessilis extract and development of sodium alginate - Alternanthera sessilis membrane for wound management

Many herbal/botanical medicines from plant sources are being used for therapeutic purpose. Alternanthera sessilis sp. plant leaves are known for their phytochemical constituents, which have potent antibacterial activity. In the present study, the properties of the A. sessilis sp. extract and the biocomposite membrane of A. sessilis sp. with sodium alginate were studied for their biomedical applications. Results showed that the A. sessilis ethanoic extract possessed high levels of antioxidant and antimicrobial activity and no cytotoxic effect under in vitro conditions. Similarly, the biocomposite membrane of alginate with the A. sessilis sp. ethanolic extract showed high antibacterial activity with hemocompatibility and swelling characteristics. Although the antioxidant, antimicrobial and cytotoxic effects of A. sessilis have been previously reported, this is the first report on the preparation of a biocomposite membrane with alginate using A. sessilis for biomedical applications.