Effects of photobiomodulation therapy with various laser power densities on wound healing

Photobiomodulation therapy (PBMT) on wound using infrared laser accelerates the wound healing process. The enhancement effects of different power densities of laser irradiation to achieve optimal result were not focused in previous works. In this study, we evaluated the effect dose-response relationship of power density below 100mW/cm(2) in PBMT with 808 nm laser. Twenty Sprague Dawley rats were divided into 6 groups; control group (GC) was a non-treated group and 5 laser treated groups with different power densities in the range of 20-100mW/cm(2). The wound was created on the dorsal region of the rats and irradiated with 808 nm laser with different power densities for 9 consecutive days except for the control group. Our results showed that the dose of 40-80mW/cm(2) power densities had beneficial effects on wound healing and 40mW/cm(2) attained maximum rate of wound healing. We conclude that power densities in PBMT effectively influenced the rate of wound healing process.