APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.

Susan Abushakra,Anton P Porsteinsson,Marwan Sabbagh,Luc Bracoud,Joel Schaerer,Aidan Power,John A Hey,David Scott,Joyce Suhy,Martin Tolar

Alzheimer's & dementia (New York, N. Y.)（2020）

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摘要

Correlation of volumetric measures to cognitive change in APOE ε4/ε4 subjects with early AD supports their role as efficacy biomarkers. If confirmed in a Phase 3 trial with ALZ-801 (pro-drug of tramiprosate) in APOE ε4/ε4 early AD subjects, it may allow their use as surrogate outcomes in future treatment or prevention trials in AD.

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关键词

ALZ‐801,Alzheimer's disease,amyloid beta,amyloid oligomers,apolipoprotein E ε4/ε4 homozygotes,biomarkers,cortical thickness,hippocampus atrophy,tramiprosate

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