LncRNA AK148321 alleviates neuroinflammation in LPS-stimulated BV2 microglial cell through regulating microRNA-1199-5p/HSPA5 axis

Shan Gao, Qiao-Chu Cheng, Ya-Guang Hu,Zi-Zhu Tan,Li Chen,Si-Wei Liu,Qian-Yan Kang,Ting Wei

Life Sciences（2021）

引用 13|浏览11

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摘要

•LPS stimulation inhibited the expression of lncRNA AK148321 in microglial cells.•LncRNA AK148321/miR-1199-5p/HSPA5 axis regulates microglial cell activation, inflammatory cytokine production, and modulates neuron cell apoptosis.•LncRNA AK148321 inhibits LPS-induced BV2 microglial cell activation and inflammation

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关键词

lncRNA AK148321,BV2 microglial cell,HSPA5,microRNA-1199-5p

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