Dynamic changes in circulating PD-1+CD8+ T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer
European Journal of Cancer（2021）
摘要
•Current biomarkers for PD-1 blockade are suboptimal and require invasive procedures.•Reduction of PD-1+ cells in CD8+ T lymphocytes predicts favourable treatment outcomes.•Suppressive function of circulating PD-1+CD8+ T lymphocytes was uncovered.
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关键词
Anti-programmed cell death-1 treatment,Non-small-cell lung cancer,CD8+ T lymphocytes,Biomarker
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