Tamoxifen induces stem-like phenotypes and multidrug resistance by altering epigenetic regulators in ERα+ breast cancer cells.

Aparna Kalyanaraman,Dhanavathy Gnanasampanthapandian, Prasad Shanmughan, Puneet Kishore,Satish Ramalingam, Rathnaswami Arunachalam,Selvaraj Jayaraman,Ilango Kaliappan,Ganesh Munuswamy-Ramanujam,Ilangovan Ramachandran,Yuvaraj Sambandam,Muralidharan Anbalagan,Parthasarathy Chandrakesan,Kanagaraj Palaniyandi

Stem cell investigation（2020）

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摘要

In the present study, we conclude that the treatment with tamoxifen induces multiple epigenetic alterations that lead to the development of MDR and stem-like phenotypes in breast cancers. Therefore, our study provides better insights to develop novel treatment regime to control the progression of breast cancer.

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关键词

Notch-1,Tamoxifen resistance (TR),breast cancer stem cells,epigenetics,multidrug resistance (MDR)

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