Screening Of Potential Antiviral Molecules Against Equid Herpesvirus-1 Using Cellular Impedance Measurement: Dataset Of 2,891 Compounds

Data presented in this article are associated with the research article "Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone and in combination"[1]. These data correspond to the in vitro screening of 2,891 potential antiviral compounds against equid herpesvirus-1 (EHV-1) based on impedance measurements using the xCELLigence (R) RTCA MP System. This dataset includes compounds from three different libraries: i) 1,199 compounds from the Prestwick (R) Chemical Library, which contains mostly US Food and Drug Administration approved drugs (Prestwick (R) Chemical, Illkirch, France); ii) 1,651 compounds from the Centre d'Etudes et de Recherche sur le Medicament de Normandie (CERMN, Caen, France); iii) 41 compounds (called herein in-house antiviral library) selected for their effects against different human viruses. Compounds effective against EHV-1 were selected using the area under normalised curves (AUC(n)) and the time required for the Cell Index to decrease by 50% after virus infection (CIT50). The full dataset from the screen is made publicly available for further analyses. (C) 2020 The Authors. Published by Elsevier Inc.