Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests.

Chelsea A Vadnie,Lauren M DePoy,Colleen A McClung

CIRCADIAN CLOCKS: Methods and Protocols（2021）

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摘要

The forced swim and tail suspension tests are commonly used to determine the effects of circadian-related pharmacological, genetic, and environmental manipulations on depression-like behavior in rodents. Both tests involve scoring immobility of rodents in an inescapable condition. Here we describe how to set up and carry out these tests.

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关键词

Antidepressant,Depression,Forced swim test,Immobility,Mice,Rats,Tail suspension test

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