Towards understanding the Regulation of Histone H1 Somatic Subtypes with OMICs

Inma Ponte,Marta Andrés,Albert Jordan,Alicia Roque

Journal of Molecular Biology（2021）

引用 2|浏览15

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摘要

•Integration of OMICs data revealed new features about histone H1 regulation.•Expression of H1 genes in TADs is higher than in boundaries.•All somatic H1 genes are targeted by cell-cycle-related transcription factors.•Transcriptional control appears to contribute to the variability of H1 composition.•Gene co-regulation may explain H1 compensatory effects and changes in development.

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关键词

co-regulation,transcription factors,subtype functional differentiation,chromatin compartments,topologically associated domains (TADs)

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